Abstract
PathwayConnector is a web-tool that facilitates the construction of complementary pathway-to-pathway networks and subnetworks of them, based on a reference pathway network derived from the rich information available either in KEGG or Reactome database for pathway mapping. Specifically, for a given set of pathways, PathwayConnector (1) finds all the direct connections between them, (2) adds a minimum set of complementary pathways required to achieve connectivity between the pathways, leading to informative fully connected networks and (3) provides a series of clustering methods for the further grouping of pathways in to sub-clusters. The proposed web-tool is a simple yet informative tool towards identifying connected groups of pathways that are significantly related to specific diseases.
http://bioinformatics.cing.ac.cy/PathwayConnector/index.php?app=PathwayConnector.
Supplementary data are available at Bioinformatics online.