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Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.

Abstract
To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.

Mendelian randomisation meta-analysis of 56 epidemiological studies.
261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers.