Read more about the article Molecular basis for mild forms of homozygous beta-thalassaemia.
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Molecular basis for mild forms of homozygous beta-thalassaemia.

Abstract Five Cypriots homozygous for beta +-thalassaemia have inherited deletion or non-deletion forms of alpha-thalassaemia that seem to have modified the usually severe clinical picture to that of mild thalassaemia…

Continue ReadingMolecular basis for mild forms of homozygous beta-thalassaemia.
Read more about the article Prevention of thalassaemia in Cyprus.
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Prevention of thalassaemia in Cyprus.

A programme for the prevention of beta-homozygous thalassaemia has been operating in Cyprus from 1973. From 1976 there has been an increasing gap between the number of homozygotes born and…

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Read more about the article The molecular basis for the haemoglobin Bart’s hydrops fetalis syndrome in Cyprus.
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The molecular basis for the haemoglobin Bart’s hydrops fetalis syndrome in Cyprus.

Continue ReadingThe molecular basis for the haemoglobin Bart’s hydrops fetalis syndrome in Cyprus.
Read more about the article Thalassaemia as a model of recessive genetic disease in the community.
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Thalassaemia as a model of recessive genetic disease in the community.

Abstract In order to gain understanding of some of the problems of genetic counseling for a severe recessive disease in England, a Greek Cypriot extended family including 87 living members…

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Read more about the article Triplicated alpha-globin loci in humans.
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Triplicated alpha-globin loci in humans.

Abstract We have identified 12 individuals who are heterozygous for a chromosome with three alpha-globin genes. We determined the presence of the third alpha-globin locus by restriction endonuclease digestion and…

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Read more about the article Molecular basis of hemoglobin-H disease in the Mediterranean population.
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Molecular basis of hemoglobin-H disease in the Mediterranean population.

Abstract We investigated the molecular basis of hemoglobin-H disease by hybridization and restriction endonuclease mapping of the DNA in the Mediterranean populations. Of the 12 patients studied from Cyprus and…

Continue ReadingMolecular basis of hemoglobin-H disease in the Mediterranean population.
Read more about the article Quantitative studies of Hb Bart’s levels and red cell indices in alpha thalassaemia trait in Mediterraneans.
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Quantitative studies of Hb Bart’s levels and red cell indices in alpha thalassaemia trait in Mediterraneans.

Abstract Haemoglobin Bart's was detected and quantitated in 42 babies during a survey of cord blood from neonates of Mediterranean origin. The distribution of Hb Bart's levels for the group…

Continue ReadingQuantitative studies of Hb Bart’s levels and red cell indices in alpha thalassaemia trait in Mediterraneans.
Read more about the article Alpha-thalassaemia in Cyprus.
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Alpha-thalassaemia in Cyprus.

Abstract The frequency of alpha-thalassaemia in Cyprus was determined with studies of haemoglobin Bart's in 1200 Greek Cypriot and 132 Turkish Cypriot newborn babies. Of the Greek newborns, 12.4%, and…

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Read more about the article Eleven cases of sickle cell disease in Sydney.
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Eleven cases of sickle cell disease in Sydney.

Abstract Eleven cases of sickle cell disease within the Sydney area are described. Eight of these are of homozygous sickle cell anaemia, and three are of the sickle cell-thalassaemia disease.…

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Read more about the article Haemoglobin Lepore in Cyprus.
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Haemoglobin Lepore in Cyprus.

Abstract Structural analysis documented the presence of haemoglobin LeporeWashington (=LeporeBoston) in a Greek Cypriot family and provided further evidence that, of the various types of Lepore mutants, only one is…

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