Read more about the article Haplotypes and levels of fetal hemoglobin and G gamma to A gamma ratios in Mediterranean patients with thalassemia minor and major.
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Haplotypes and levels of fetal hemoglobin and G gamma to A gamma ratios in Mediterranean patients with thalassemia minor and major.

Abstract This study concerned the gamma chain composition of Hb F and the haplotypes of 44 patients with beta-thalassemia major or intermedia and many of their relatives. Seventeen patients came…

Continue ReadingHaplotypes and levels of fetal hemoglobin and G gamma to A gamma ratios in Mediterranean patients with thalassemia minor and major.
Read more about the article Feasibility of prenatal diagnosis of beta-thalassaemia with synthetic DNA probes in two Mediterranean populations.
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Feasibility of prenatal diagnosis of beta-thalassaemia with synthetic DNA probes in two Mediterranean populations.

Abstract A feasibility study in two Mediterranean populations showed that prenatal diagnosis of beta-thalassaemia with a limited number of synthetic oligonucleotide probes would have been possible in about 70% of…

Continue ReadingFeasibility of prenatal diagnosis of beta-thalassaemia with synthetic DNA probes in two Mediterranean populations.
Read more about the article Alpha zero-thalassemia due to recombination between the alpha 1-globin gene and an AluI repeat.
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Alpha zero-thalassemia due to recombination between the alpha 1-globin gene and an AluI repeat.

Abstract A form of alpha zero-thalassemia found in subjects of Mediterranean origin has been analyzed by gene mapping and DNA sequencing. Homozygotes have the hemoglobin Bart's hydrops fetalis syndrome, while…

Continue ReadingAlpha zero-thalassemia due to recombination between the alpha 1-globin gene and an AluI repeat.
Read more about the article The comparative value of prospective and retrospective fetal diagnosis in preventing inherited disease.
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The comparative value of prospective and retrospective fetal diagnosis in preventing inherited disease.

Abstract

Continue ReadingThe comparative value of prospective and retrospective fetal diagnosis in preventing inherited disease.
Read more about the article A new DNA polymorphism for prenatal diagnosis of beta-thalassaemia in Mediterranean populations.
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A new DNA polymorphism for prenatal diagnosis of beta-thalassaemia in Mediterranean populations.

Abstract The prevalence of a new polymorphism for the restriction enzyme Ava II in the psi beta-gene of the beta-globin gene cluster was determined in Mediterranean families with at least…

Continue ReadingA new DNA polymorphism for prenatal diagnosis of beta-thalassaemia in Mediterranean populations.
Read more about the article Feasibility of antenatal diagnosis of beta thalassaemia by DNA polymorphisms in Asian Indian and Cypriot populations.
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Feasibility of antenatal diagnosis of beta thalassaemia by DNA polymorphisms in Asian Indian and Cypriot populations.

Abstract The feasibility of using restriction fragment length polymorphisms ( RFLPs ) for the antenatal diagnosis of beta thalassaemia in the U.K.-resident Cypriot and Asian Indian populations has been determined.…

Continue ReadingFeasibility of antenatal diagnosis of beta thalassaemia by DNA polymorphisms in Asian Indian and Cypriot populations.
Read more about the article Haemoglobin O Arab (B121 Glu-Lys) in Turkish Cypriot population.
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Haemoglobin O Arab (B121 Glu-Lys) in Turkish Cypriot population.

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Abstract

Continue ReadingHaemoglobin O Arab (B121 Glu-Lys) in Turkish Cypriot population.
Read more about the article Association of two DNA polymorphisms in the alpha-globin gene cluster: implications for genetic analysis.
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Association of two DNA polymorphisms in the alpha-globin gene cluster: implications for genetic analysis.

Abstract A new polymorphic BgI II restriction endonuclease site in the alpha-globin gene complex has been found in Cypriot, Sardinian, and Greek populations. In all cases, this polymorphism is linked…

Continue ReadingAssociation of two DNA polymorphisms in the alpha-globin gene cluster: implications for genetic analysis.
Read more about the article Globin gene mapping studies in Sardinian patients homozygous for beta zero Thalassaemia.
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Globin gene mapping studies in Sardinian patients homozygous for beta zero Thalassaemia.

Abstract The genetic factors responsible for the relatively mild clinical phenotypes of some cases of homozygous beta zero thalassaemia (thalassaemia intermedia) in Sardinia have been evaluated. The frequency of deletion…

Continue ReadingGlobin gene mapping studies in Sardinian patients homozygous for beta zero Thalassaemia.