Read more about the article Genetic defects in the cyp21a2 gene in heterozygous girls with premature adrenarche and adolescent females with hyperandrogenemia.
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Genetic defects in the cyp21a2 gene in heterozygous girls with premature adrenarche and adolescent females with hyperandrogenemia.

Abstract Congenital adrenal hyperplasia (CAH) is a common autosomal recessive disorder primarily caused by mutants in the CYP21A2 gene. Heterozygosity for CYP21A2 mutations in females increases their risk of clinically…

Continue ReadingGenetic defects in the cyp21a2 gene in heterozygous girls with premature adrenarche and adolescent females with hyperandrogenemia.
Read more about the article Investigation of SCA10 in the Cypriot population: further exclusion of SCA dynamic repeat mutations.
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Investigation of SCA10 in the Cypriot population: further exclusion of SCA dynamic repeat mutations.

Abstract Autosomal dominant cerebellar ataxias (ADCAs) encompass a heterogeneous group of rare diseases that affect the cerebellum and its connections. The most common forms have been associated with dynamic mutations…

Continue ReadingInvestigation of SCA10 in the Cypriot population: further exclusion of SCA dynamic repeat mutations.
Read more about the article KIF1Bβ transports dendritically localized mRNPs in neurons and is recruited to synapses in an activity-dependent manner.
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KIF1Bβ transports dendritically localized mRNPs in neurons and is recruited to synapses in an activity-dependent manner.

Abstract KIF1Bβ is a kinesin-like, microtubule-based molecular motor protein involved in anterograde axonal vesicular transport in vertebrate and invertebrate neurons. Certain KIF1Bβ isoforms have been implicated in different forms of…

Continue ReadingKIF1Bβ transports dendritically localized mRNPs in neurons and is recruited to synapses in an activity-dependent manner.
Read more about the article A report of 2 new cases of MODY2 and review of the literature: implications in the search for type 2 diabetes drugs.
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A report of 2 new cases of MODY2 and review of the literature: implications in the search for type 2 diabetes drugs.

Abstract Glucokinase (GCK) acts as a glucose sensor and stimulates the release of insulin from pancreatic β-cells and any GCK gene mutations can lead to different forms of diabetes, such…

Continue ReadingA report of 2 new cases of MODY2 and review of the literature: implications in the search for type 2 diabetes drugs.
Read more about the article Mediterranean diet, overweight and body composition in children from eight European countries: cross-sectional and prospective results from the IDEFICS study.
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Mediterranean diet, overweight and body composition in children from eight European countries: cross-sectional and prospective results from the IDEFICS study.

Abstract A Mediterranean-like dietary pattern has been shown to be inversely associated with many diseases, but its role in early obesity prevention is not clear. We aimed to determine if…

Continue ReadingMediterranean diet, overweight and body composition in children from eight European countries: cross-sectional and prospective results from the IDEFICS study.
Read more about the article Developmental stage- and concentration-specific sodium nitroprusside application results in nitrate reductase regulation and the modification of nitrate metabolism in leaves of Medicago truncatula plants.
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Developmental stage- and concentration-specific sodium nitroprusside application results in nitrate reductase regulation and the modification of nitrate metabolism in leaves of Medicago truncatula plants.

Abstract Nitric oxide (NO) is a bioactive molecule involved in numerous biological events that has been reported to display both pro-oxidant and antioxidant properties in plants. Several reports exist which…

Continue ReadingDevelopmental stage- and concentration-specific sodium nitroprusside application results in nitrate reductase regulation and the modification of nitrate metabolism in leaves of Medicago truncatula plants.
Read more about the article Pax6 is expressed in subsets of V0 and V2 interneurons in the ventral spinal cord in mice.
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Pax6 is expressed in subsets of V0 and V2 interneurons in the ventral spinal cord in mice.

Abstract The embryonic spinal cord in mice is organized into eleven progenitor domains. Cells in each domain first produce neurons and then switch to specifying glia. Five of these domains…

Continue ReadingPax6 is expressed in subsets of V0 and V2 interneurons in the ventral spinal cord in mice.
Read more about the article Single fiber electromyography: what type of needle should I use?
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Single fiber electromyography: what type of needle should I use?

Abstract

Continue ReadingSingle fiber electromyography: what type of needle should I use?
Read more about the article Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.
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Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.

Abstract The purpose of this work is to determine the molecular mechanisms underlying tamoxifen resistance. We show here that ER-β is epigenetically silenced in a cell line with acquired tamoxifen…

Continue ReadingReversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.
Read more about the article Intraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration.
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Intraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration.

Abstract In amyotrophic lateral sclerosis (ALS) reactive oxygen species and apoptosis are implicated in disease pathogenesis. Melatonin with its anti-oxidant and anti-apoptotic properties is expected to ameliorate disease phenotype. The…

Continue ReadingIntraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration.