Read more about the article FCGR polymorphisms and cetuximab efficacy in chemorefractory metastatic colorectal cancer: an international consortium study.
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FCGR polymorphisms and cetuximab efficacy in chemorefractory metastatic colorectal cancer: an international consortium study.

Abstract We aimed to better clarify the role of germline variants of the FCG2 receptor, FCGR2A-H131R and FCGR3A-V158F, on the therapeutic efficacy of cetuximab in metastatic colorectal cancer (mCRC). A…

Continue ReadingFCGR polymorphisms and cetuximab efficacy in chemorefractory metastatic colorectal cancer: an international consortium study.
Read more about the article Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.
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Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.

Abstract To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. Mendelian randomisation meta-analysis of…

Continue ReadingAssociation between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.
Read more about the article Molecular analysis of Cypriot patients with Glutaric aciduria type I: identification of two novel mutations.
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Molecular analysis of Cypriot patients with Glutaric aciduria type I: identification of two novel mutations.

Abstract The purpose of this study was to identify the mutations in the glutaryl-CoA dehydrogenase gene (GCDH) in ten Cypriot patients with Glutaric aciduria type I (GAI). Molecular analysis of…

Continue ReadingMolecular analysis of Cypriot patients with Glutaric aciduria type I: identification of two novel mutations.
Read more about the article Reference values of bone stiffness index and C-terminal telopeptide in healthy European children.
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Reference values of bone stiffness index and C-terminal telopeptide in healthy European children.

Abstract Quantitative ultrasound measurements and bone metabolic markers can help to monitor bone health and to detect impaired skeletal development. Population-based reference values for children may serve as a basis…

Continue ReadingReference values of bone stiffness index and C-terminal telopeptide in healthy European children.
Read more about the article Physical fitness reference standards in European children: the IDEFICS study.
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Physical fitness reference standards in European children: the IDEFICS study.

Abstract A low fitness status during childhood and adolescence is associated with important health-related outcomes, such as increased future risk for obesity and cardiovascular diseases, impaired skeletal health, reduced quality…

Continue ReadingPhysical fitness reference standards in European children: the IDEFICS study.
Read more about the article A genome-wide pleiotropy scan for prostate cancer risk.
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A genome-wide pleiotropy scan for prostate cancer risk.

Abstract No single-nucleotide polymorphisms (SNPs) specific for aggressive prostate cancer have been identified in genome-wide association studies (GWAS). To test if SNPs associated with other traits may also affect the…

Continue ReadingA genome-wide pleiotropy scan for prostate cancer risk.
Read more about the article Population genetic data for 15 autosomal STR markers in Turkish Cypriots from Cyprus.
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Population genetic data for 15 autosomal STR markers in Turkish Cypriots from Cyprus.

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Abstract Fifteen autosomal short tandem repeat (STR) markers [D8S1179, D21S11, D7S820, CSF1PO, D3S1358, THO1, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA] were analyzed in 501 unrelated, randomly…

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Read more about the article Poor embryo development and preimplantation genetic diagnosis outcomes of translocations involving chromosome 10: Do we blame genetics?
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Poor embryo development and preimplantation genetic diagnosis outcomes of translocations involving chromosome 10: Do we blame genetics?

Abstract Balanced reciprocal translocation carriers are usually phenotypically normal. Although the reproductive risk of these carriers varies, they generally have a lower chance to produce normal or balanced gametes. Preimplantation…

Continue ReadingPoor embryo development and preimplantation genetic diagnosis outcomes of translocations involving chromosome 10: Do we blame genetics?
Read more about the article Interplay between GST and nitric oxide in the early response of soybean (Glycine max L.) plants to salinity stress.
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Interplay between GST and nitric oxide in the early response of soybean (Glycine max L.) plants to salinity stress.

Abstract Glutathione-s-transferases (GSTs) and nitric oxide (NO) have both been implicated in the response of plants to salinity stress. However, their interplay and underlying mechanisms are relatively unknown. The present…

Continue ReadingInterplay between GST and nitric oxide in the early response of soybean (Glycine max L.) plants to salinity stress.
Read more about the article Reference values of whole-blood fatty acids by age and sex from European children aged 3-8 years.
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Reference values of whole-blood fatty acids by age and sex from European children aged 3-8 years.

Abstract To establish reference values for fatty acids (FA) especially for n-3 and n-6 long-chain polyunsaturated FAs (LC PUFA) in whole-blood samples from apparently healthy 3-8-year-old European children. The whole-blood…

Continue ReadingReference values of whole-blood fatty acids by age and sex from European children aged 3-8 years.