Screening for carriers of recessive disease.
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Abstract We used restriction endonuclease analysis to determine the incidence of alpha-thalassemia in two Mediterranean islands. In a random population sample, the gene frequency of deletion-type alpha-thalassemia-2 (-alpha) was 0.18…
Abstract A case-finding survey yielded 58 persons with transfusion-dependent homozygous beta-thalassaemia who lived either in New South Wales or in the Australian Capital Territory. Of those born between 1961 and…
Abstract A study, which was intended to find out the main causes of defective vision among Kuwaiti students, yielded the following results: The percentage of defective vision among 139,769 Kuwaiti…
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Abstract We have identified the beta-thalassaemia alleles in nearly all known Turkish Cypriot beta-thalassaemia homozygotes and in over 700 Greek Cypriot beta-thalassaemia heterozygotes living on the island of Cyprus. The…
Abstract The polymorphic sites across the beta gene cluster (restriction haplotypes) in association with specific thalassaemic mutations were analyzed in representative samples of normal and thalassaemic Greeks in comparison to…