Thalassaemia as a model of recessive genetic disease in the community.
Abstract
In order to gain understanding of some of the problems of genetic counseling for a severe recessive disease in England, a Greek...
Triplicated alpha-globin loci in humans.
Abstract
We have identified 12 individuals who are heterozygous for a chromosome with three alpha-globin genes. We determined the presence of the third...
Molecular basis of hemoglobin-H disease in the Mediterranean population.
Abstract
We investigated the molecular basis of hemoglobin-H disease by hybridization and restriction endonuclease mapping of the DNA in the Mediterranean populations. Of...
Quantitative studies of Hb Bart’s levels and red cell indices in alpha thalassaemia trait in Mediterraneans.
Abstract
Haemoglobin Bart's was detected and quantitated in 42 babies during a survey of cord blood from neonates of Mediterranean origin. The distribution...
Alpha-thalassaemia in Cyprus.
Abstract
The frequency of alpha-thalassaemia in Cyprus was determined with studies of haemoglobin Bart's in 1200 Greek Cypriot and 132 Turkish Cypriot newborn...
Eleven cases of sickle cell disease in Sydney.
Abstract
Eleven cases of sickle cell disease within the Sydney area are described. Eight of these are of homozygous sickle cell anaemia, and...
Haemoglobin Lepore in Cyprus.
Abstract
Structural analysis documented the presence of haemoglobin LeporeWashington (=LeporeBoston) in a Greek Cypriot family and provided further evidence that, of the various...
Childhood blindness in Lebanon.
Abstract
A survey in the Lebanese schools for the blind revealed that 77% of childhood blindness in the country was genetically determined. Two...