Read more about the article Therapeutic potential of omega-3 fatty acids supplementation in a mouse model of dry macular degeneration.
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Therapeutic potential of omega-3 fatty acids supplementation in a mouse model of dry macular degeneration.

Abstract To evaluate the therapeutic effects of omega-3 (ω-3) and omega-6 (ω-6) fatty acids in the CCL2 model of dry age-related macular degeneration (AMD). The blood level of eicosapentaenoic acid…

Continue ReadingTherapeutic potential of omega-3 fatty acids supplementation in a mouse model of dry macular degeneration.
Read more about the article Evaluation of the impact of sperm morphology on embryo aneuploidy rates in a donor oocyte program.
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Evaluation of the impact of sperm morphology on embryo aneuploidy rates in a donor oocyte program.

Abstract This study investigates the correlation between sperm morphology and the incidence of embryo aneuploidy in an oocyte donation program. A total of 1,165 embryos from 103 patients have been…

Continue ReadingEvaluation of the impact of sperm morphology on embryo aneuploidy rates in a donor oocyte program.
Read more about the article Evaluation of nipple aspirate fluid as a diagnostic tool for early detection of breast cancer.
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Evaluation of nipple aspirate fluid as a diagnostic tool for early detection of breast cancer.

Abstract There has been tremendous progress in detection of breast cancer in postmenopausal women, resulting in two-thirds of women surviving more than 20 years after treatment. However, breast cancer remains the…

Continue ReadingEvaluation of nipple aspirate fluid as a diagnostic tool for early detection of breast cancer.
Read more about the article Rapid and Sensitive Assessment of Globin Chains for Gene and Cell Therapy of Hemoglobinopathies.
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Rapid and Sensitive Assessment of Globin Chains for Gene and Cell Therapy of Hemoglobinopathies.

Abstract The β-hemoglobinopathies sickle cell anemia and β-thalassemia are the focus of many gene-therapy studies. A key disease parameter is the abundance of globin chains because it indicates the level…

Continue ReadingRapid and Sensitive Assessment of Globin Chains for Gene and Cell Therapy of Hemoglobinopathies.
Read more about the article Arterial tortuosity syndrome: 40 new families and literature review.
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Arterial tortuosity syndrome: 40 new families and literature review.

Abstract PurposeWe delineate the clinical spectrum and describe the histology in arterial tortuosity syndrome (ATS), a rare connective tissue disorder characterized by tortuosity of the large and medium-sized arteries, caused…

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Read more about the article Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium.
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Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium.

Abstract Polygenic risk scores (PRS) for breast cancer can be used to stratify the population into groups at substantially different levels of risk. Combining PRS and environmental risk factors will…

Continue ReadingJoint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium.
Read more about the article MicroRNAs as possible biomarkers for screening of aortic aneurysms: a systematic review and validation study.
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MicroRNAs as possible biomarkers for screening of aortic aneurysms: a systematic review and validation study.

Abstract There is an urgent need to identify non-invasive biomarkers for the early detection of aortic aneurysms, preceding a fatal event. The potential role for MicroRNAs (miRNAs) as diagnostic markers…

Continue ReadingMicroRNAs as possible biomarkers for screening of aortic aneurysms: a systematic review and validation study.
Read more about the article GnRH-dependent precocious puberty manifested at the age of 14 months in a girl with 47,XXX karyotype.
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GnRH-dependent precocious puberty manifested at the age of 14 months in a girl with 47,XXX karyotype.

Abstract This case report describes a 47,XXX girl who presented very early, at the age of 14 months, with signs of sexual precocity (breast and pubic hair development, menarche) and…

Continue ReadingGnRH-dependent precocious puberty manifested at the age of 14 months in a girl with 47,XXX karyotype.
Read more about the article Epigenetic Changes in the CRH Gene are Related to Severity of Suicide Attempt and a General Psychiatric Risk Score in Adolescents.
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Epigenetic Changes in the CRH Gene are Related to Severity of Suicide Attempt and a General Psychiatric Risk Score in Adolescents.

Abstract The aim of this study, comprising 88 suicide attempters, was to identify hypothalamic-pituitary-adrenal (HPA) -axis coupled CpG-sites showing methylation shifts linked to severity of the suicide attempt. Candidate methylation…

Continue ReadingEpigenetic Changes in the CRH Gene are Related to Severity of Suicide Attempt and a General Psychiatric Risk Score in Adolescents.
Read more about the article Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Abstract Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from…

Continue ReadingProtein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.