Read more about the article Adherence to combined lifestyle factors and their contribution to obesity in the IDEFICS study.
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Adherence to combined lifestyle factors and their contribution to obesity in the IDEFICS study.

Abstract The Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS (IDEFICS) study investigated the aetiology of childhood obesity and developed a primary prevention programme. Pre-intervention…

Continue ReadingAdherence to combined lifestyle factors and their contribution to obesity in the IDEFICS study.
Read more about the article Fat, sugar and water intakes among families from the IDEFICS intervention and control groups: first observations from I.Family.
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Fat, sugar and water intakes among families from the IDEFICS intervention and control groups: first observations from I.Family.

Abstract The objective of this paper is to investigate differences in diets of families in intervention versus control communities 5 years after the Identification and Prevention of Dietary- and Lifestyle-Induced Health…

Continue ReadingFat, sugar and water intakes among families from the IDEFICS intervention and control groups: first observations from I.Family.
Read more about the article Differential outcome of the IDEFICS intervention in overweight versus non-overweight children: did we achieve ‘primary’ or ‘secondary’ prevention?
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Differential outcome of the IDEFICS intervention in overweight versus non-overweight children: did we achieve ‘primary’ or ‘secondary’ prevention?

Abstract The aim of this study was to explore whether the IDEFICS intervention had a differential effect on 11,041 children's weight trajectories depending on their baseline body mass index status.…

Continue ReadingDifferential outcome of the IDEFICS intervention in overweight versus non-overweight children: did we achieve ‘primary’ or ‘secondary’ prevention?
Read more about the article A ligand-independent integrin β1 mechanosensory complex guides spindle orientation.
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A ligand-independent integrin β1 mechanosensory complex guides spindle orientation.

Abstract Control of spindle orientation is a fundamental process for embryonic development, morphogenesis and tissue homeostasis, while defects are associated with tumorigenesis and other diseases. Force sensing is one of…

Continue ReadingA ligand-independent integrin β1 mechanosensory complex guides spindle orientation.
Read more about the article Titin antibodies in "seronegative" myasthenia gravis–A new role for an old antigen.
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Titin antibodies in "seronegative" myasthenia gravis–A new role for an old antigen.

Abstract Myasthenia gravis (MG) is an autoimmune disease caused by antibodies targeting the neuromuscular junction of skeletal muscles. Triple-seronegative MG (tSN-MG, without detectable AChR, MuSK and LRP4 antibodies), which accounts…

Continue ReadingTitin antibodies in "seronegative" myasthenia gravis–A new role for an old antigen.
Read more about the article Sequence evidence for common ancestry of eukaryotic endomembrane coatomers.
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Sequence evidence for common ancestry of eukaryotic endomembrane coatomers.

Abstract Eukaryotic cells are defined by compartments through which the trafficking of macromolecules is mediated by large complexes, such as the nuclear pore, transport vesicles and intraflagellar transport. The assembly…

Continue ReadingSequence evidence for common ancestry of eukaryotic endomembrane coatomers.
Read more about the article No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.
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No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.

Abstract BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group family of DNA repair proteins. Biallelic mutations in BRIP1 are responsible for FANC…

Continue ReadingNo evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.
Read more about the article Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells.
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Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells.

Abstract The mechanism of endoplasmic reticulum (ER) morphogenesis is incompletely understood. ER tubules are shaped by the reticulons (RTNs) and DP1/Yop1p family members, but the mechanism of ER sheet formation…

Continue ReadingTransmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells.
Read more about the article Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status.
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Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status.

Abstract Hepatocellular carcinoma is the second deadliest cancer with limited treatment options. Loss of PTEN causes the P13K/Akt pathway to be hyperactive which contributes to cell survival and resistance to…

Continue ReadingLiver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status.
Read more about the article Early Life Factors and Inter-Country Heterogeneity in BMI Growth Trajectories of European Children: The IDEFICS Study.
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Early Life Factors and Inter-Country Heterogeneity in BMI Growth Trajectories of European Children: The IDEFICS Study.

Abstract Starting from birth, this explorative study aimed to investigate between-country differences in body mass index (BMI) trajectories and whether early life factors explain these differences. The sample included 7,644…

Continue ReadingEarly Life Factors and Inter-Country Heterogeneity in BMI Growth Trajectories of European Children: The IDEFICS Study.