Read more about the article Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status.
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Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status.

Abstract Hepatocellular carcinoma is the second deadliest cancer with limited treatment options. Loss of PTEN causes the P13K/Akt pathway to be hyperactive which contributes to cell survival and resistance to…

Continue ReadingLiver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status.
Read more about the article Early Life Factors and Inter-Country Heterogeneity in BMI Growth Trajectories of European Children: The IDEFICS Study.
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Early Life Factors and Inter-Country Heterogeneity in BMI Growth Trajectories of European Children: The IDEFICS Study.

Abstract Starting from birth, this explorative study aimed to investigate between-country differences in body mass index (BMI) trajectories and whether early life factors explain these differences. The sample included 7,644…

Continue ReadingEarly Life Factors and Inter-Country Heterogeneity in BMI Growth Trajectories of European Children: The IDEFICS Study.
Read more about the article Pilot Experience with an External Quality Assurance Scheme for Acylcarnitines in Plasma/Serum.
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Pilot Experience with an External Quality Assurance Scheme for Acylcarnitines in Plasma/Serum.

Abstract The analysis of acylcarnitines (AC) in plasma/serum is established as a useful test for the biochemical diagnosis and the monitoring of treatment of organic acidurias and fatty acid oxidation…

Continue ReadingPilot Experience with an External Quality Assurance Scheme for Acylcarnitines in Plasma/Serum.
Read more about the article Integrase Strand Transfer Inhibitors (INSTIs) Resistance Mutations in HIV-1 Infected Turkish Patients.
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Integrase Strand Transfer Inhibitors (INSTIs) Resistance Mutations in HIV-1 Infected Turkish Patients.

Abstract Integrase strand transfer inhibitor (INSTI) is a new class of antiretroviral (ARV) drugs designed to block the action of the integrase viral enzyme, which is responsible for insertation of…

Continue ReadingIntegrase Strand Transfer Inhibitors (INSTIs) Resistance Mutations in HIV-1 Infected Turkish Patients.
Read more about the article Novel GLA Deletion in a Cypriot Female Presenting with Cornea Verticillata.
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Novel GLA Deletion in a Cypriot Female Presenting with Cornea Verticillata.

Abstract Fabry disease is an X-linked lysosomal storage disorder resulting from a deficiency of the hydrolytic enzyme α-galactosidase A (α-Gal-A). It is characterized by progressive lysosomal accumulation of globotriaosylceramide (Gb3)…

Continue ReadingNovel GLA Deletion in a Cypriot Female Presenting with Cornea Verticillata.
Read more about the article Evaluation of the genetic parameters for 10 common and five new ESS core autosomal STR loci in seven major geographic regions and the largest metropolitan province of Turkey.
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Evaluation of the genetic parameters for 10 common and five new ESS core autosomal STR loci in seven major geographic regions and the largest metropolitan province of Turkey.

Abstract Situated at the crossroads of Asia, Middle East and Europe, Turkey has an ethnically diverse population of over 78 milllion people. To investigate the population genetics and potential differences…

Continue ReadingEvaluation of the genetic parameters for 10 common and five new ESS core autosomal STR loci in seven major geographic regions and the largest metropolitan province of Turkey.
Read more about the article Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.
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Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.

Abstract The diagnosis of hematologic malignancies relies on multidisciplinary workflows involving morphology, flow cytometry, cytogenetic, and molecular genetic analyses. Advances in cancer genomics have identified numerous recurrent mutations with clear…

Continue ReadingDevelopment and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.
Read more about the article Cell-Free DNA Analysis of Targeted Genomic Regions in Maternal Plasma for Non-Invasive Prenatal Testing of Trisomy 21, Trisomy 18, Trisomy 13, and Fetal Sex.
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Cell-Free DNA Analysis of Targeted Genomic Regions in Maternal Plasma for Non-Invasive Prenatal Testing of Trisomy 21, Trisomy 18, Trisomy 13, and Fetal Sex.

Abstract There is great need for the development of highly accurate cost effective technologies that could facilitate the widespread adoption of noninvasive prenatal testing (NIPT). We developed an assay based…

Continue ReadingCell-Free DNA Analysis of Targeted Genomic Regions in Maternal Plasma for Non-Invasive Prenatal Testing of Trisomy 21, Trisomy 18, Trisomy 13, and Fetal Sex.
Read more about the article Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells.
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Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells.

Abstract Acquired resistance towards apoptosis is a hallmark of cancer. Elimination of cells bearing activated oncogenes or stimulation of tumor suppressor mediators may provide a selection pressure to overcome resistance.…

Continue ReadingSelective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells.
Read more about the article Efficacy of neck circumference to identify metabolic syndrome in 3-10 year-old European children: Results from IDEFICS study.
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Efficacy of neck circumference to identify metabolic syndrome in 3-10 year-old European children: Results from IDEFICS study.

Abstract Several studies demonstrated that larger neck circumference (NC) in children and adolescents may help to identify obesity and cardio-metabolic abnormalities. We aimed to evaluate the correlation between NC and…

Continue ReadingEfficacy of neck circumference to identify metabolic syndrome in 3-10 year-old European children: Results from IDEFICS study.