Read more about the article Follicle-Stimulating Hormone Receptor (FSHR): A Promising Tool in Oncology?
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Follicle-Stimulating Hormone Receptor (FSHR): A Promising Tool in Oncology?

Abstract The cellular pathway of follicle-stimulating hormone (FSH) and its receptor (FSHR) is typically involved in reproduction in mammals. In humans, the FSHR is normally found in cells of the…

Continue ReadingFollicle-Stimulating Hormone Receptor (FSHR): A Promising Tool in Oncology?
Read more about the article The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study.
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The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study.

Abstract Ninety-four common genetic variants are confirmed to be associated with breast cancer. This study tested the hypothesis that breast cancer susceptibility variants may also be associated with chemotherapy-induced toxicity…

Continue ReadingThe Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study.
Read more about the article ESMO consensus guidelines for the management of patients with metastatic colorectal cancer.
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ESMO consensus guidelines for the management of patients with metastatic colorectal cancer.

Abstract Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients…

Continue ReadingESMO consensus guidelines for the management of patients with metastatic colorectal cancer.
Read more about the article Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation.
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Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation.

Abstract Congenital adrenal hyperplasia (CAH) is an endocrine autosomal recessive disorder with various symptoms of diverse severity. Mild hyperandrogenemia is the most commonclinical feature in non-classic CAH patients and 95%…

Continue ReadingGenetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation.
Read more about the article RARβ gene methylation is a candidate for primary glioblastoma treatment planning.
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RARβ gene methylation is a candidate for primary glioblastoma treatment planning.

Abstract We screened RARβ methylation in primary glioblastoma multiforme (GBM) and the results were evaluated based on the clinical data and treatment type. The objective of this study was to…

Continue ReadingRARβ gene methylation is a candidate for primary glioblastoma treatment planning.
Read more about the article Deregulated microRNA expression and its pathogenetic implications for myelodysplastic syndromes.
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Deregulated microRNA expression and its pathogenetic implications for myelodysplastic syndromes.

Abstract Myelodysplastic syndromes (MDS) include a heterogeneous group of clonal hematological stem cell disorders characterized by ineffective hematopoiesis, cytopenias. MicroRNAs (miRNAs) are short non-coding RNA molecules that repress gene expression…

Continue ReadingDeregulated microRNA expression and its pathogenetic implications for myelodysplastic syndromes.
Read more about the article Turkish Cypriot paternal lineages bear an autochthonous character and closest resemblance to those from neighbouring Near Eastern populations.
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Turkish Cypriot paternal lineages bear an autochthonous character and closest resemblance to those from neighbouring Near Eastern populations.

Abstract Cyprus is an island in the Eastern Mediterranean Sea with a documented history of human settlements dating back over 10,000 years. To investigate the paternal lineages of a representative…

Continue ReadingTurkish Cypriot paternal lineages bear an autochthonous character and closest resemblance to those from neighbouring Near Eastern populations.
Read more about the article Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.
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Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.

Abstract Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell…

Continue ReadingPharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.
Read more about the article Suppression of MTHFD2 in MCF-7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion.
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Suppression of MTHFD2 in MCF-7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion.

Abstract Methylenetetrahydrofolate dehydrogenase (NAD(P)+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2) is a mitochondrial enzyme involved in folate metabolism. A number of recent studies have highlighted this enzyme as being highly expressed…

Continue ReadingSuppression of MTHFD2 in MCF-7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion.
Read more about the article Investigating the Effect of Hydroalcoholic Extract of Cyperus rotundus L. on the Expression of Bcl-x1 Antiapoptotic Gene in Rats’ Hippocampus Tissue Following Global Ischemic-Reperfusion Injury.
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Investigating the Effect of Hydroalcoholic Extract of Cyperus rotundus L. on the Expression of Bcl-x1 Antiapoptotic Gene in Rats’ Hippocampus Tissue Following Global Ischemic-Reperfusion Injury.

Abstract Ischemia-reperfusion injury is the tissue damage happened when blood supply returns to the tissue after a period of ischemia or shortage of oxygen. This brain injury initiates an inflammatory…

Continue ReadingInvestigating the Effect of Hydroalcoholic Extract of Cyperus rotundus L. on the Expression of Bcl-x1 Antiapoptotic Gene in Rats’ Hippocampus Tissue Following Global Ischemic-Reperfusion Injury.