Read more about the article Genomic and genetic studies of systemic sclerosis: A systematic review.
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Genomic and genetic studies of systemic sclerosis: A systematic review.

Abstract Systemic sclerosis is an autoimmune rheumatic disease characterised by fibrosis, vasculopathy and inflammation. The exact aetiology of SSc remains unknown but evidences show that various genetic factors may be…

Continue ReadingGenomic and genetic studies of systemic sclerosis: A systematic review.
Read more about the article Prevalence of primary ciliary dyskinesia in consecutive referrals of suspect cases and the transmission electron microscopy detection rate: a systematic review and meta-analysis.
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Prevalence of primary ciliary dyskinesia in consecutive referrals of suspect cases and the transmission electron microscopy detection rate: a systematic review and meta-analysis.

Abstract Diagnostic testing for primary ciliary dyskinesia (PCD) usually includes transmission electron microscopy (TEM), nasal nitric oxide, high-speed video microscopy, and genetics. Diagnostic performance of each test should be assessed…

Continue ReadingPrevalence of primary ciliary dyskinesia in consecutive referrals of suspect cases and the transmission electron microscopy detection rate: a systematic review and meta-analysis.
Read more about the article Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae.
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Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae.

Abstract Transcriptome studies have revealed that many eukaryotic genomes are pervasively transcribed producing numerous long non-coding RNAs (lncRNAs). However, only a few lncRNAs have been ascribed a cellular role thus…

Continue ReadingFunctional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae.
Read more about the article Methylation of HPA axis related genes in men with hypersexual disorder.
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Methylation of HPA axis related genes in men with hypersexual disorder.

Abstract Hypersexual Disorder (HD) defined as non-paraphilic sexual desire disorder with components of compulsivity, impulsivity and behavioral addiction, and proposed as a diagnosis in the DSM 5, shares some overlapping…

Continue ReadingMethylation of HPA axis related genes in men with hypersexual disorder.
Read more about the article Calorie restriction breaks an epigenetic barrier to longevity.
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Calorie restriction breaks an epigenetic barrier to longevity.

Abstract

Continue ReadingCalorie restriction breaks an epigenetic barrier to longevity.
Read more about the article Prospective associations between dietary patterns and high sensitivity C-reactive protein in European children: the IDEFICS study.
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Prospective associations between dietary patterns and high sensitivity C-reactive protein in European children: the IDEFICS study.

Abstract This prospective study explores high sensitivity C-reactive protein (hs-CRP) levels in relation to dietary patterns at two time points in European children. Out of the baseline sample of the…

Continue ReadingProspective associations between dietary patterns and high sensitivity C-reactive protein in European children: the IDEFICS study.
Read more about the article Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.
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Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.

Abstract Breast cancer risks conferred by many germline missense variants in the and genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study,…

Continue ReadingHypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.
Read more about the article Further evidence for the role of pregnancy-induced hypertension and other early life influences in the development of ADHD: results from the IDEFICS study.
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Further evidence for the role of pregnancy-induced hypertension and other early life influences in the development of ADHD: results from the IDEFICS study.

Abstract The aim of this study is to investigate whether in addition to established early risk factors other, less studied pre-, peri-, and postnatal influences, like gestational hypertension or neonatal…

Continue ReadingFurther evidence for the role of pregnancy-induced hypertension and other early life influences in the development of ADHD: results from the IDEFICS study.
Read more about the article The role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort.
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The role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort.

Abstract Neuromedin U (NMU) is a hypothalamic neuropeptide with important roles in several metabolic processes, recently suggested as potential therapeutic target for obesity. We analysed the associations between NMU gene…

Continue ReadingThe role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort.
Read more about the article Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPA).
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Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPA).

Abstract A hallmark of cancer cells is their ability to invade surrounding tissues and form metastases. Cell-extracellular matrix (ECM)-adhesion proteins are crucial in metastasis, connecting tumor ECM with actin cytoskeleton…

Continue ReadingVasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPA).