Read more about the article Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes.
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Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes.

Abstract This report describes the use of trans-splicing ribozymes to restore p16 protein synthesis in pancreatic cancer cells. A group I intron ribozyme was designed to trans-splice the 2 base-deleted…

Continue ReadingRestoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes.
Read more about the article Distribution and functions of kinectin isoforms.
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Distribution and functions of kinectin isoforms.

Abstract Kinectin is an integral transmembrane protein on the endoplasmic reticulum, binding to kinesin, interacting with Rho GTPase and anchoring the translation elongation factor-1 complex. There has been debate on…

Continue ReadingDistribution and functions of kinectin isoforms.
Read more about the article MAPH: from gels to microarrays.
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MAPH: from gels to microarrays.

Abstract The development of accurate and sensitive methodologies to detect small chromosomal imbalances (<3 Mb) is extremely important in clinical diagnostics and research in human genetics. The technique of array-comparative…

Continue ReadingMAPH: from gels to microarrays.
Read more about the article The MTHFR 677TT and 677CT/1298AC genotypes in Cypriot patients may be predisposing to hypertensive nephrosclerosis and chronic renal failure.
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The MTHFR 677TT and 677CT/1298AC genotypes in Cypriot patients may be predisposing to hypertensive nephrosclerosis and chronic renal failure.

Abstract The homozygous 677TT mutation of the MTHFR gene has been linked to deep vein thrombosis and to arterial atherosclerotic events of the coronary, carotid and peripheral arteries. Its putative…

Continue ReadingThe MTHFR 677TT and 677CT/1298AC genotypes in Cypriot patients may be predisposing to hypertensive nephrosclerosis and chronic renal failure.
Read more about the article Multiplex molecular diagnosis of MEFV mutations in patients with familial Mediterranean fever by LightCycler real-time PCR.
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Multiplex molecular diagnosis of MEFV mutations in patients with familial Mediterranean fever by LightCycler real-time PCR.

Abstract

Continue ReadingMultiplex molecular diagnosis of MEFV mutations in patients with familial Mediterranean fever by LightCycler real-time PCR.
Read more about the article Vestibular symptoms and signs are correlated with abnormal neurogenic vestibular evoked potentials in patients with multiple sclerosis.
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Vestibular symptoms and signs are correlated with abnormal neurogenic vestibular evoked potentials in patients with multiple sclerosis.

Abstract Symptoms of disequilibrium in multiple sclerosis (MS) are common. Neurogenic vestibular evoked potentials (NVsEPs) are saccular responses to tone-pip acoustic stimuli and are recordable from the parietal areas ipsilaterally…

Continue ReadingVestibular symptoms and signs are correlated with abnormal neurogenic vestibular evoked potentials in patients with multiple sclerosis.
Read more about the article Potential therapy paradigms for Marfan syndrome.
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Potential therapy paradigms for Marfan syndrome.

Abstract Marfan syndrome is the most common genetic disorder of the connective tissue with an estimated prevalence of 1:10,000. The disease is characterised by manifestations in the cardiovascular, skeletal and…

Continue ReadingPotential therapy paradigms for Marfan syndrome.
Read more about the article The Arg482His mutation in the beta-galactosidase gene is responsible for a high frequency of GM1 gangliosidosis carriers in a Cypriot village.
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The Arg482His mutation in the beta-galactosidase gene is responsible for a high frequency of GM1 gangliosidosis carriers in a Cypriot village.

Abstract GM1 gangliosidosis is a lysosomal storage disorder caused by deficiency of beta-galactosidase. It is mainly characterized by progressive neurodegeneration, and in its most severe infantile form, it leads to…

Continue ReadingThe Arg482His mutation in the beta-galactosidase gene is responsible for a high frequency of GM1 gangliosidosis carriers in a Cypriot village.
Read more about the article Blood lead levels in preprimary school-age children in Nicosia, Cyprus, and their relationship with leaded soil dust exposure.
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Blood lead levels in preprimary school-age children in Nicosia, Cyprus, and their relationship with leaded soil dust exposure.

Abstract The authors conducted a cross-sectional study to determine blood lead levels in children who attended kindergarten schools and nurseries in Nicosia, Cyprus, and to correlate their findings with (a)…

Continue ReadingBlood lead levels in preprimary school-age children in Nicosia, Cyprus, and their relationship with leaded soil dust exposure.