Read more about the article Gene delivery targeted to oligodendrocytes using a lentiviral vector.
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Gene delivery targeted to oligodendrocytes using a lentiviral vector.

Abstract Most leukodystrophies result from mutations in genes expressed in oligodendrocytes that may cause autonomous loss of function of cell structural proteins. Therefore, effective gene delivery to oligodendrocytes is necessary…

Continue ReadingGene delivery targeted to oligodendrocytes using a lentiviral vector.
Read more about the article Familial Mediterranean fever associated with MEFV mutations in a large cohort of Cypriot patients.
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Familial Mediterranean fever associated with MEFV mutations in a large cohort of Cypriot patients.

Abstract Familial Mediterranean fever (FMF) is caused by mutations in the MEFV gene and the spectrum of mutations among Greek-Cypriots with FMF-related symptoms was examined. Sequence analysis for exons 2,…

Continue ReadingFamilial Mediterranean fever associated with MEFV mutations in a large cohort of Cypriot patients.
Read more about the article Molecular epidemiology of rhinoviruses in Cyprus over three consecutive seasons.
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Molecular epidemiology of rhinoviruses in Cyprus over three consecutive seasons.

Abstract Human rhinoviruses (HRVs) are widespread respiratory pathogens and a major cause of acute respiratory tract infections. The aim of this study was to investigate the molecular epidemiology of rhinovirus…

Continue ReadingMolecular epidemiology of rhinoviruses in Cyprus over three consecutive seasons.
Read more about the article Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review).
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Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review).

Abstract Deregulation of cell signaling homeostasis is a predominant feature of cancer initiation and progression. Transforming growth factor β (TGFβ) is a pleiotropic cytokine, which regulates numerous biological processes of…

Continue ReadingRole of TGFβ in regulation of the tumor microenvironment and drug delivery (review).
Read more about the article Prevalence of overweight and obesity in European children below the age of 10.
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Prevalence of overweight and obesity in European children below the age of 10.

Abstract There is a lack of common surveillance systems providing comparable figures and temporal trends of the prevalence of overweight (OW), obesity and related risk factors among European preschool and…

Continue ReadingPrevalence of overweight and obesity in European children below the age of 10.
Read more about the article Prospective associations between socio-economic status and dietary patterns in European children: the Identification and Prevention of Dietary- and Lifestyle-induced Health Effects in Children and Infants (IDEFICS) Study.
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Prospective associations between socio-economic status and dietary patterns in European children: the Identification and Prevention of Dietary- and Lifestyle-induced Health Effects in Children and Infants (IDEFICS) Study.

Abstract Exploring changes in children's diet over time and the relationship between these changes and socio-economic status (SES) may help to understand the impact of social inequalities on dietary patterns.…

Continue ReadingProspective associations between socio-economic status and dietary patterns in European children: the Identification and Prevention of Dietary- and Lifestyle-induced Health Effects in Children and Infants (IDEFICS) Study.
Read more about the article Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.
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Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.

Abstract Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial…

Continue ReadingMosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.
Read more about the article Phenotypic variability of hyperandrogenemia in females heterozygous for CYP21A2 mutations.
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Phenotypic variability of hyperandrogenemia in females heterozygous for CYP21A2 mutations.

Abstract The objective was to seek evidence on the prevalence and consequences of heterozygous CYP21A2 mutations in girls, adolescent, and adult females with clinical manifestation of androgen excess. The study…

Continue ReadingPhenotypic variability of hyperandrogenemia in females heterozygous for CYP21A2 mutations.
Read more about the article Transgenic replacement of Cx32 in gap junction-deficient oligodendrocytes rescues the phenotype of a hypomyelinating leukodystrophy model.
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Transgenic replacement of Cx32 in gap junction-deficient oligodendrocytes rescues the phenotype of a hypomyelinating leukodystrophy model.

Abstract Oligodendrocytes are coupled by gap junctions (GJs) formed mainly by connexin47 (Cx47) and Cx32. Recessive GJC2/Cx47 mutations cause Pelizaeus-Merzbacher-like disease, a hypomyelinating leukodystrophy, while GJB1/Cx32 mutations cause neuropathy and…

Continue ReadingTransgenic replacement of Cx32 in gap junction-deficient oligodendrocytes rescues the phenotype of a hypomyelinating leukodystrophy model.
Read more about the article Frequency of COL4A3/COL4A4 mutations amongst families segregating glomerular microscopic hematuria and evidence for activation of the unfolded protein response. Focal and segmental glomerulosclerosis is a frequent development during ageing.
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Frequency of COL4A3/COL4A4 mutations amongst families segregating glomerular microscopic hematuria and evidence for activation of the unfolded protein response. Focal and segmental glomerulosclerosis is a frequent development during ageing.

Abstract Familial glomerular hematuria(s) comprise a genetically heterogeneous group of conditions which include Alport Syndrome (AS) and thin basement membrane nephropathy (TBMN). Here we investigated 57 Greek-Cypriot families presenting glomerular…

Continue ReadingFrequency of COL4A3/COL4A4 mutations amongst families segregating glomerular microscopic hematuria and evidence for activation of the unfolded protein response. Focal and segmental glomerulosclerosis is a frequent development during ageing.