Read more about the article Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review).
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Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review).

Abstract Deregulation of cell signaling homeostasis is a predominant feature of cancer initiation and progression. Transforming growth factor β (TGFβ) is a pleiotropic cytokine, which regulates numerous biological processes of…

Continue ReadingRole of TGFβ in regulation of the tumor microenvironment and drug delivery (review).
Read more about the article Prospective associations between socio-economic status and dietary patterns in European children: the Identification and Prevention of Dietary- and Lifestyle-induced Health Effects in Children and Infants (IDEFICS) Study.
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Prospective associations between socio-economic status and dietary patterns in European children: the Identification and Prevention of Dietary- and Lifestyle-induced Health Effects in Children and Infants (IDEFICS) Study.

Abstract Exploring changes in children's diet over time and the relationship between these changes and socio-economic status (SES) may help to understand the impact of social inequalities on dietary patterns.…

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Read more about the article Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.
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Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.

Abstract Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial…

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Read more about the article Phenotypic variability of hyperandrogenemia in females heterozygous for CYP21A2 mutations.
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Phenotypic variability of hyperandrogenemia in females heterozygous for CYP21A2 mutations.

Abstract The objective was to seek evidence on the prevalence and consequences of heterozygous CYP21A2 mutations in girls, adolescent, and adult females with clinical manifestation of androgen excess. The study…

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Read more about the article Transgenic replacement of Cx32 in gap junction-deficient oligodendrocytes rescues the phenotype of a hypomyelinating leukodystrophy model.
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Transgenic replacement of Cx32 in gap junction-deficient oligodendrocytes rescues the phenotype of a hypomyelinating leukodystrophy model.

Abstract Oligodendrocytes are coupled by gap junctions (GJs) formed mainly by connexin47 (Cx47) and Cx32. Recessive GJC2/Cx47 mutations cause Pelizaeus-Merzbacher-like disease, a hypomyelinating leukodystrophy, while GJB1/Cx32 mutations cause neuropathy and…

Continue ReadingTransgenic replacement of Cx32 in gap junction-deficient oligodendrocytes rescues the phenotype of a hypomyelinating leukodystrophy model.
Read more about the article Frequency of COL4A3/COL4A4 mutations amongst families segregating glomerular microscopic hematuria and evidence for activation of the unfolded protein response. Focal and segmental glomerulosclerosis is a frequent development during ageing.
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Frequency of COL4A3/COL4A4 mutations amongst families segregating glomerular microscopic hematuria and evidence for activation of the unfolded protein response. Focal and segmental glomerulosclerosis is a frequent development during ageing.

Abstract Familial glomerular hematuria(s) comprise a genetically heterogeneous group of conditions which include Alport Syndrome (AS) and thin basement membrane nephropathy (TBMN). Here we investigated 57 Greek-Cypriot families presenting glomerular…

Continue ReadingFrequency of COL4A3/COL4A4 mutations amongst families segregating glomerular microscopic hematuria and evidence for activation of the unfolded protein response. Focal and segmental glomerulosclerosis is a frequent development during ageing.
Read more about the article Global Dispersal Pattern of HIV Type 1 Subtype CRF01_AE: A Genetic Trace of Human Mobility Related to Heterosexual Sexual Activities Centralized in Southeast Asia.
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Global Dispersal Pattern of HIV Type 1 Subtype CRF01_AE: A Genetic Trace of Human Mobility Related to Heterosexual Sexual Activities Centralized in Southeast Asia.

Abstract Human immunodeficiency virus type 1 (HIV-1) subtype CRF01_AE originated in Africa and then passed to Thailand, where it established a major epidemic. Despite the global presence of CRF01_AE, little…

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Read more about the article Genetic defects of the CYP21A2 gene in girls with premature adrenarche.
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Genetic defects of the CYP21A2 gene in girls with premature adrenarche.

Abstract To seek evidence on the prevalence of CYP21A2 genetic defects and consequences in girls with premature adrenarche (PA). The study included 59 girls diagnosed with PA. Direct DNA sequencing…

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Read more about the article Incidence of high blood pressure in children – effects of physical activity and sedentary behaviors: the IDEFICS study: High blood pressure, lifestyle and children.
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Incidence of high blood pressure in children – effects of physical activity and sedentary behaviors: the IDEFICS study: High blood pressure, lifestyle and children.

Abstract High blood pressure (HBP) is one of the most important risk factors for cardiovascular diseases and it has a high prevalence in pediatric populations. However, the determinants of the…

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Read more about the article Connexins, gap junctions and peripheral neuropathy.
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Connexins, gap junctions and peripheral neuropathy.

Abstract Gap junctions (GJs) have emerged as an important molecular component of peripheral myelinated fibers following the discovery of mutations affecting the GJ protein connexin32 (Cx32) in patients with the…

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