Read more about the article Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.
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Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.

Abstract The purpose of this work is to determine the molecular mechanisms underlying tamoxifen resistance. We show here that ER-β is epigenetically silenced in a cell line with acquired tamoxifen…

Continue ReadingReversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.
Read more about the article Intraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration.
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Intraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration.

Abstract In amyotrophic lateral sclerosis (ALS) reactive oxygen species and apoptosis are implicated in disease pathogenesis. Melatonin with its anti-oxidant and anti-apoptotic properties is expected to ameliorate disease phenotype. The…

Continue ReadingIntraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration.
Read more about the article Cross-talk among epigenetic modifications: lessons from histone arginine methylation.
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Cross-talk among epigenetic modifications: lessons from histone arginine methylation.

Abstract Epigenetic modifications, including those occurring on DNA and on histone proteins, control gene expression by establishing and maintaining different chromatin states. In recent years, it has become apparent that…

Continue ReadingCross-talk among epigenetic modifications: lessons from histone arginine methylation.
Read more about the article The HPV16 oncogenes cause aberrant stem cell mobilization.
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The HPV16 oncogenes cause aberrant stem cell mobilization.

Abstract Human Papilloma Virus related epithelial cancers have been speculated to derive from virus-infected tissue stem cells. Stem cells also are thought to provide a reservoir of latently infected cells…

Continue ReadingThe HPV16 oncogenes cause aberrant stem cell mobilization.
Read more about the article Turkish perspective of Jervell and Lange-Nielsen syndrome.
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Turkish perspective of Jervell and Lange-Nielsen syndrome.

Abstract

Continue ReadingTurkish perspective of Jervell and Lange-Nielsen syndrome.
Read more about the article EFNS review on the role of muscle biopsy in the investigation of myalgia.
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EFNS review on the role of muscle biopsy in the investigation of myalgia.

Abstract Myalgia, defined as any pain perceived in muscle, is very common in the general population and a frequent cause for referral to neurologists, rheumatologists and internists in general. It…

Continue ReadingEFNS review on the role of muscle biopsy in the investigation of myalgia.
Read more about the article Comment on "technical concerns on the clinical validation of the NIFTY test".
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Comment on "technical concerns on the clinical validation of the NIFTY test".

Abstract

Continue ReadingComment on "technical concerns on the clinical validation of the NIFTY test".
Read more about the article Variability of ffDNA in maternal plasma does not prevent correct classification of trisomy 21 using MeDIP-qPCR methodology.
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Variability of ffDNA in maternal plasma does not prevent correct classification of trisomy 21 using MeDIP-qPCR methodology.

Abstract The goal of this study is to evaluate the amount of free fetal DNA (ffDNA), total DNA, and 'fetal fraction' found in maternal plasma and whether these influence the…

Continue ReadingVariability of ffDNA in maternal plasma does not prevent correct classification of trisomy 21 using MeDIP-qPCR methodology.
Read more about the article Reconstruction of the evolutionary dynamics of hepatitis C virus subtypes in Montenegro and the Balkan region.
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Reconstruction of the evolutionary dynamics of hepatitis C virus subtypes in Montenegro and the Balkan region.

Abstract More than 20 million hepatitis C virus (HCV) carriers live in the countries of the Eastern Mediterranean. We determined HCV genotype distribution among chronically infected patients in Montenegro and…

Continue ReadingReconstruction of the evolutionary dynamics of hepatitis C virus subtypes in Montenegro and the Balkan region.
Read more about the article High carrier frequency of 21-hydroxylase deficiency in Cyprus.
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High carrier frequency of 21-hydroxylase deficiency in Cyprus.

Abstract Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is a common autosomal recessive disorder caused by mutations in the CYP21A2 gene. The carrier frequency of CYP21A2 mutations has…

Continue ReadingHigh carrier frequency of 21-hydroxylase deficiency in Cyprus.