Read more about the article Improving health care services in Northern Cyprus: a call for research and action.
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Improving health care services in Northern Cyprus: a call for research and action.

Abstract

Continue ReadingImproving health care services in Northern Cyprus: a call for research and action.
Read more about the article Environmental margin and island evolution in Middle Eastern populations of the Egyptian fruit bat.
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Environmental margin and island evolution in Middle Eastern populations of the Egyptian fruit bat.

Abstract Here, we present a study of the population genetic architecture and microevolution of the Egyptian fruit bat (Rousettus aegyptiacus) at the environmental margins in the Middle East using mitochondrial…

Continue ReadingEnvironmental margin and island evolution in Middle Eastern populations of the Egyptian fruit bat.
Read more about the article Maternal plasma sequencing: a powerful tool towards fetal whole genome recovery.
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Maternal plasma sequencing: a powerful tool towards fetal whole genome recovery.

Abstract Noninvasive prenatal diagnosis of chromosomal aneuploidies, although challenging, has been achieved through the implementation of novel methodologies such as methylated DNA immunoprecipitation and next generation sequencing technologies. Nevertheless, additional…

Continue ReadingMaternal plasma sequencing: a powerful tool towards fetal whole genome recovery.
Read more about the article δ0-Thalassemia in cis of βKnossos globin gene: first homozygous description in thalassemia intermedia Libyans and first combination with codon 39 (C→T) in thalassemia intermedia Tunisian patients.
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δ0-Thalassemia in cis of βKnossos globin gene: first homozygous description in thalassemia intermedia Libyans and first combination with codon 39 (C→T) in thalassemia intermedia Tunisian patients.

Abstract β-Thalassemia is the most common disease among hemoglobinopathies in North African and Arab populations. In the present study we report the first description of the β-Knossos codon27 (G→T) (βKnossos)…

Continue Readingδ0-Thalassemia in cis of βKnossos globin gene: first homozygous description in thalassemia intermedia Libyans and first combination with codon 39 (C→T) in thalassemia intermedia Tunisian patients.
Read more about the article A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis.
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A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis.

Abstract The unfolded protein response (UPR) is a major signalling cascade acting in the quality control of protein folding in the endoplasmic reticulum (ER). The cascade is known to play…

Continue ReadingA mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis.
Read more about the article Genetic defects in the cyp21a2 gene in heterozygous girls with premature adrenarche and adolescent females with hyperandrogenemia.
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Genetic defects in the cyp21a2 gene in heterozygous girls with premature adrenarche and adolescent females with hyperandrogenemia.

Abstract Congenital adrenal hyperplasia (CAH) is a common autosomal recessive disorder primarily caused by mutants in the CYP21A2 gene. Heterozygosity for CYP21A2 mutations in females increases their risk of clinically…

Continue ReadingGenetic defects in the cyp21a2 gene in heterozygous girls with premature adrenarche and adolescent females with hyperandrogenemia.
Read more about the article Pax6 is expressed in subsets of V0 and V2 interneurons in the ventral spinal cord in mice.
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Pax6 is expressed in subsets of V0 and V2 interneurons in the ventral spinal cord in mice.

Abstract The embryonic spinal cord in mice is organized into eleven progenitor domains. Cells in each domain first produce neurons and then switch to specifying glia. Five of these domains…

Continue ReadingPax6 is expressed in subsets of V0 and V2 interneurons in the ventral spinal cord in mice.
Read more about the article Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.
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Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.

Abstract The purpose of this work is to determine the molecular mechanisms underlying tamoxifen resistance. We show here that ER-β is epigenetically silenced in a cell line with acquired tamoxifen…

Continue ReadingReversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.
Read more about the article Intraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration.
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Intraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration.

Abstract In amyotrophic lateral sclerosis (ALS) reactive oxygen species and apoptosis are implicated in disease pathogenesis. Melatonin with its anti-oxidant and anti-apoptotic properties is expected to ameliorate disease phenotype. The…

Continue ReadingIntraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration.
Read more about the article Cross-talk among epigenetic modifications: lessons from histone arginine methylation.
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Cross-talk among epigenetic modifications: lessons from histone arginine methylation.

Abstract Epigenetic modifications, including those occurring on DNA and on histone proteins, control gene expression by establishing and maintaining different chromatin states. In recent years, it has become apparent that…

Continue ReadingCross-talk among epigenetic modifications: lessons from histone arginine methylation.