Read more about the article Calorie restriction breaks an epigenetic barrier to longevity.
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Calorie restriction breaks an epigenetic barrier to longevity.

Abstract

Continue ReadingCalorie restriction breaks an epigenetic barrier to longevity.
Read more about the article Prospective associations between dietary patterns and high sensitivity C-reactive protein in European children: the IDEFICS study.
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Prospective associations between dietary patterns and high sensitivity C-reactive protein in European children: the IDEFICS study.

Abstract This prospective study explores high sensitivity C-reactive protein (hs-CRP) levels in relation to dietary patterns at two time points in European children. Out of the baseline sample of the…

Continue ReadingProspective associations between dietary patterns and high sensitivity C-reactive protein in European children: the IDEFICS study.
Read more about the article Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.
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Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.

Abstract Breast cancer risks conferred by many germline missense variants in the and genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study,…

Continue ReadingHypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.
Read more about the article Further evidence for the role of pregnancy-induced hypertension and other early life influences in the development of ADHD: results from the IDEFICS study.
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Further evidence for the role of pregnancy-induced hypertension and other early life influences in the development of ADHD: results from the IDEFICS study.

Abstract The aim of this study is to investigate whether in addition to established early risk factors other, less studied pre-, peri-, and postnatal influences, like gestational hypertension or neonatal…

Continue ReadingFurther evidence for the role of pregnancy-induced hypertension and other early life influences in the development of ADHD: results from the IDEFICS study.
Read more about the article The role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort.
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The role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort.

Abstract Neuromedin U (NMU) is a hypothalamic neuropeptide with important roles in several metabolic processes, recently suggested as potential therapeutic target for obesity. We analysed the associations between NMU gene…

Continue ReadingThe role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort.
Read more about the article Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPA).
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Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPA).

Abstract A hallmark of cancer cells is their ability to invade surrounding tissues and form metastases. Cell-extracellular matrix (ECM)-adhesion proteins are crucial in metastasis, connecting tumor ECM with actin cytoskeleton…

Continue ReadingVasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPA).
Read more about the article Association Between the Probability of Autism Spectrum Disorder and Normative Sex-Related Phenotypic Diversity in Brain Structure.
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Association Between the Probability of Autism Spectrum Disorder and Normative Sex-Related Phenotypic Diversity in Brain Structure.

Abstract Autism spectrum disorder (ASD) is 2 to 5 times more common in male individuals than in female individuals. While the male preponderant prevalence of ASD might partially be explained…

Continue ReadingAssociation Between the Probability of Autism Spectrum Disorder and Normative Sex-Related Phenotypic Diversity in Brain Structure.
Read more about the article TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer.
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TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer.

Abstract TP53 overexpression is indicative of somatic TP53 mutations and associates with aggressive tumors and poor prognosis in breast cancer. We utilized a two-stage SNP association study to detect variants…

Continue ReadingTP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer.
Read more about the article Re-analysis of unassigned hepatitis C virus (HCV) strain CYHCV025: Evidence of a highly divergent lineage within genotype 1.
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Re-analysis of unassigned hepatitis C virus (HCV) strain CYHCV025: Evidence of a highly divergent lineage within genotype 1.

Abstract HCV global sequences have been classified into 7 genotypes, several subtypes and a number of unassigned sequences. Our aim was to perform an in depth investigation of the taxonomic…

Continue ReadingRe-analysis of unassigned hepatitis C virus (HCV) strain CYHCV025: Evidence of a highly divergent lineage within genotype 1.
Read more about the article Sudden unexplained death in the young: epidemiology, aetiology and value of the clinically guided genetic screening.
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Sudden unexplained death in the young: epidemiology, aetiology and value of the clinically guided genetic screening.

Abstract To determine the incidence and the causes of sudden death (SD) in persons aged 1-35 years old and the diagnostic yield of clinically guided genetic screening in the sudden…

Continue ReadingSudden unexplained death in the young: epidemiology, aetiology and value of the clinically guided genetic screening.