Read more about the article Axonal pathology precedes demyelination in a mouse model of X-linked demyelinating/type I Charcot-Marie Tooth neuropathy.
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Axonal pathology precedes demyelination in a mouse model of X-linked demyelinating/type I Charcot-Marie Tooth neuropathy.

Abstract The X-linked demyelinating/type I Charcot-Marie-Tooth neuropathy (CMT1X) is an inherited peripheral neuropathy caused by mutations in GJB1, the gene that encodes the gap junction protein connexin32. Connexin32 is expressed…

Continue ReadingAxonal pathology precedes demyelination in a mouse model of X-linked demyelinating/type I Charcot-Marie Tooth neuropathy.
Read more about the article The application of ribozymes and DNAzymes in muscle and brain.
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The application of ribozymes and DNAzymes in muscle and brain.

Abstract The discovery of catalytic nucleic acids (CNAs) has provided scientists with valuable tools for the identification of new therapies for several untreated diseases through down regulation or modulation of…

Continue ReadingThe application of ribozymes and DNAzymes in muscle and brain.
Read more about the article ThalassoChip, an array mutation and single nucleotide polymorphism detection tool for the diagnosis of β-thalassaemia.
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ThalassoChip, an array mutation and single nucleotide polymorphism detection tool for the diagnosis of β-thalassaemia.

Abstract The detection and diagnosis of β-thalassaemia for populations with molecular heterogeneity, or diverse ethnic groups, has increased the need for the development of an array high-throughput diagnostic tool that…

Continue ReadingThalassoChip, an array mutation and single nucleotide polymorphism detection tool for the diagnosis of β-thalassaemia.
Read more about the article Tackling the pathogenesis of RNA nuclear retention in myotonic dystrophy.
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Tackling the pathogenesis of RNA nuclear retention in myotonic dystrophy.

Abstract DM1 (myotonic dystrophy type I) is a common form of muscular dystrophy that affects mainly adults. It is a disease that belongs to the group of defective RNA export…

Continue ReadingTackling the pathogenesis of RNA nuclear retention in myotonic dystrophy.
Read more about the article Molecular mechanisms of gap junction mutations in myelinating cells.
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Molecular mechanisms of gap junction mutations in myelinating cells.

Abstract There is an emerging group of neurological disorders that result from genetic mutations affecting gap junction proteins in myelinating cells. The X-linked form of Charcot Marie Tooth disease (CMT1X)…

Continue ReadingMolecular mechanisms of gap junction mutations in myelinating cells.
Read more about the article Effect of drought and rewatering on the cellular status and antioxidant response of Medicago truncatula plants.
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Effect of drought and rewatering on the cellular status and antioxidant response of Medicago truncatula plants.

Abstract Effects of water stress on plants have been well-documented. However, the combined responses to drought and rewatering and their underlying mechanisms are relatively unknown. The present study attempts to…

Continue ReadingEffect of drought and rewatering on the cellular status and antioxidant response of Medicago truncatula plants.
Read more about the article Gap junction disorders of myelinating cells.
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Gap junction disorders of myelinating cells.

Abstract Gap junctions (GJs) are channels that allow the diffusion of ions and small molecules across apposed cell membranes. In peripheral nerves, Schwann cells express the GJ proteins connexin32 (Cx32)…

Continue ReadingGap junction disorders of myelinating cells.
Read more about the article Replication of genome-wide discovered breast cancer risk loci in the Cypriot population.
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Replication of genome-wide discovered breast cancer risk loci in the Cypriot population.

Abstract Genome-wide association studies (GWAS) have identified associations with robust statistical support for influencing breast cancer susceptibility. Most GWAS and replications have been conducted in Northern European populations and to…

Continue ReadingReplication of genome-wide discovered breast cancer risk loci in the Cypriot population.
Read more about the article A computationally fast measure of epistasis for 2 SNPs and a categorical phenotype.
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A computationally fast measure of epistasis for 2 SNPs and a categorical phenotype.

Abstract Complex diseases may be caused by interactions or combined effects between multiple genetic and environmental factors. One of the main limitations of testing for interaction between genetic loci in…

Continue ReadingA computationally fast measure of epistasis for 2 SNPs and a categorical phenotype.
Read more about the article The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition.
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The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition.

Abstract hCINAP is an atypical nucleoplasmic enzyme, combining structural features of adenylate kinases and ATPases, which exhibits dual enzymatic activity. It interacts with the Cajal Body marker coilin and its…

Continue ReadingThe nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition.