Read more about the article Expression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle.
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Expression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle.

Abstract MicroRNAs (miRNAs) are small RNA molecules that post-transcriptionally regulate gene expression and have been shown to play an important role during development. miR-1, miR-133a, miR-133b and miR-206 are expressed…

Continue ReadingExpression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle.
Read more about the article Endocrine profile and phenotype-genotype correlation in unrelated patients with non-classical congenital adrenal hyperplasia.
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Endocrine profile and phenotype-genotype correlation in unrelated patients with non-classical congenital adrenal hyperplasia.

Abstract The aim of this study was to identify the molecular defect in a group of 37 unrelated Greek Cypriot patients affected by NC-CAH and evaluate the relationship between the…

Continue ReadingEndocrine profile and phenotype-genotype correlation in unrelated patients with non-classical congenital adrenal hyperplasia.
Read more about the article Computational protein design with a generalized Born solvent model: application to Asparaginyl-tRNA synthetase.
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Computational protein design with a generalized Born solvent model: application to Asparaginyl-tRNA synthetase.

Abstract Computational Protein Design (CPD) is a promising method for high throughput protein and ligand mutagenesis. Recently, we developed a CPD method that used a polar-hydrogen energy function for protein…

Continue ReadingComputational protein design with a generalized Born solvent model: application to Asparaginyl-tRNA synthetase.
Read more about the article Increased number of microRNA target sites in genes encoded in CNV regions. Evidence for an evolutionary genomic interaction.
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Increased number of microRNA target sites in genes encoded in CNV regions. Evidence for an evolutionary genomic interaction.

Abstract MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome…

Continue ReadingIncreased number of microRNA target sites in genes encoded in CNV regions. Evidence for an evolutionary genomic interaction.
Read more about the article Regulating complement in the kidney: insights from CFHR5 nephropathy.
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Regulating complement in the kidney: insights from CFHR5 nephropathy.

Abstract Complement factor H related protein 5 (CFHR5) nephropathy is a monogenic disorder of complement regulation that is endemic in Cyprus. The disease is characterised by haematuria, C3 glomerulonephritis and…

Continue ReadingRegulating complement in the kidney: insights from CFHR5 nephropathy.
Read more about the article Analysis of enterovirus and adenovirus presence in swimming pools in Cyprus from 2007-2008.
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Analysis of enterovirus and adenovirus presence in swimming pools in Cyprus from 2007-2008.

Abstract An analysis was carried out to determine the presence of enteroviruses and adenoviruses in public swimming pools in Cyprus. The effectiveness of the commonly implemented disinfection procedure of chlorination…

Continue ReadingAnalysis of enterovirus and adenovirus presence in swimming pools in Cyprus from 2007-2008.
Read more about the article Testing alternative hypotheses for evolutionary diversification in an African songbird: rainforest refugia versus ecological gradients.
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Testing alternative hypotheses for evolutionary diversification in an African songbird: rainforest refugia versus ecological gradients.

Abstract Geographic isolation in rainforest refugia and local adaptation to ecological gradients may both be important drivers of evolutionary diversification. However, their relative importance and the underlying mechanisms of these…

Continue ReadingTesting alternative hypotheses for evolutionary diversification in an African songbird: rainforest refugia versus ecological gradients.
Read more about the article Near-full genome characterization of unclassified hepatitis C virus strains relating to genotypes 1 and 4.
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Near-full genome characterization of unclassified hepatitis C virus strains relating to genotypes 1 and 4.

Abstract Near-full genome sequences are presented in this report for the first time of unclassified HCV strains amplified using RT-PCR from plasma of patients living in Cyprus. One strain appears…

Continue ReadingNear-full genome characterization of unclassified hepatitis C virus strains relating to genotypes 1 and 4.
Read more about the article BioTextQuest: a web-based biomedical text mining suite for concept discovery.
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BioTextQuest: a web-based biomedical text mining suite for concept discovery.

Abstract BioTextQuest combines automated discovery of significant terms in article clusters with structured knowledge annotation, via Named Entity Recognition services, offering interactive user-friendly visualization. A tag-cloud-based illustration of terms labeling…

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Read more about the article Design of a modified mouse protein with ligand binding properties of its human analog by molecular dynamics simulations: the case of C3 inhibition by compstatin.
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Design of a modified mouse protein with ligand binding properties of its human analog by molecular dynamics simulations: the case of C3 inhibition by compstatin.

Abstract The peptide compstatin and its derivatives inhibit the complement-component protein C3 in primate mammals and are potential therapeutic agents against the unregulated activation of complement in humans, but are…

Continue ReadingDesign of a modified mouse protein with ligand binding properties of its human analog by molecular dynamics simulations: the case of C3 inhibition by compstatin.