Read more about the article A fast and efficient algorithm for mapping short sequences to a reference genome.
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A fast and efficient algorithm for mapping short sequences to a reference genome.

Abstract Novel high-throughput (Deep) sequencing technology methods have redefined the way genome sequencing is performed. They are able to produce tens of millions of short sequences (reads) in a single…

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Read more about the article Molecular defects of the CYP21A2 gene in Greek-Cypriot patients with congenital adrenal hyperplasia.
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Molecular defects of the CYP21A2 gene in Greek-Cypriot patients with congenital adrenal hyperplasia.

Abstract To determine the mutations in the CYP21A2 gene in Greek-Cypriots with congenital adrenal hyperplasia (CAH) and attempt a genotype-phenotype correlation. Molecular analysis was performed by multiplex ligation-dependent probe amplification…

Continue ReadingMolecular defects of the CYP21A2 gene in Greek-Cypriot patients with congenital adrenal hyperplasia.
Read more about the article Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways.
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Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways.

Abstract Polycystic Kidney Disease is characterized by the formation of large fluid-filled cysts that eventually destroy the renal parenchyma leading to end-stage renal failure. Although remarkable progress has been made…

Continue ReadingCyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways.
Read more about the article Hydrophilic cationic star homopolymers based on a novel diethanol-N-methylamine dimethacrylate cross-linker for siRNA transfection: synthesis, characterization, and evaluation.
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Hydrophilic cationic star homopolymers based on a novel diethanol-N-methylamine dimethacrylate cross-linker for siRNA transfection: synthesis, characterization, and evaluation.

Abstract Four cationic hydrophilic star homopolymers based on the novel hydrophilic, positively ionizable cross-linker bis(methacryloyloxyethyl)methylamine (BMEMA) were synthesized using sequential group transfer polymerization (GTP) and were, subsequently, evaluated for their…

Continue ReadingHydrophilic cationic star homopolymers based on a novel diethanol-N-methylamine dimethacrylate cross-linker for siRNA transfection: synthesis, characterization, and evaluation.
Read more about the article X-linked Alport syndrome in Hellenic families: phenotypic heterogeneity and mutations near interruptions of the collagen domain in COL4A5.
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X-linked Alport syndrome in Hellenic families: phenotypic heterogeneity and mutations near interruptions of the collagen domain in COL4A5.

Abstract The X-linked Alport syndrome (ATS) is caused by mutations in COL4A5 and exhibits a widely variable expression. Usually ATS is heralded with continuous microhematuria which rapidly progresses to proteinuria,…

Continue ReadingX-linked Alport syndrome in Hellenic families: phenotypic heterogeneity and mutations near interruptions of the collagen domain in COL4A5.
Read more about the article Effect of drought and rewatering on the cellular status and antioxidant response of Medicago truncatula plants.
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Effect of drought and rewatering on the cellular status and antioxidant response of Medicago truncatula plants.

Abstract Effects of water stress on plants have been well-documented. However, the combined responses to drought and rewatering and their underlying mechanisms are relatively unknown. The present study attempts to…

Continue ReadingEffect of drought and rewatering on the cellular status and antioxidant response of Medicago truncatula plants.
Read more about the article Gap junction disorders of myelinating cells.
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Gap junction disorders of myelinating cells.

Abstract Gap junctions (GJs) are channels that allow the diffusion of ions and small molecules across apposed cell membranes. In peripheral nerves, Schwann cells express the GJ proteins connexin32 (Cx32)…

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Read more about the article BioTextQuest: a web-based biomedical text mining suite for concept discovery.
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BioTextQuest: a web-based biomedical text mining suite for concept discovery.

Abstract BioTextQuest combines automated discovery of significant terms in article clusters with structured knowledge annotation, via Named Entity Recognition services, offering interactive user-friendly visualization. A tag-cloud-based illustration of terms labeling…

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Read more about the article Design of a modified mouse protein with ligand binding properties of its human analog by molecular dynamics simulations: the case of C3 inhibition by compstatin.
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Design of a modified mouse protein with ligand binding properties of its human analog by molecular dynamics simulations: the case of C3 inhibition by compstatin.

Abstract The peptide compstatin and its derivatives inhibit the complement-component protein C3 in primate mammals and are potential therapeutic agents against the unregulated activation of complement in humans, but are…

Continue ReadingDesign of a modified mouse protein with ligand binding properties of its human analog by molecular dynamics simulations: the case of C3 inhibition by compstatin.
Read more about the article Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery.
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Thrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery.

Abstract Emerging perioperative genomics may influence the direction of risk assessment and surgical strategies in cardiac surgery. The aim of this study was to investigate whether single nucleotide polymorphisms (SNP)…

Continue ReadingThrombotic gene polymorphisms and postoperative outcome after coronary artery bypass graft surgery.