Read more about the article Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells.
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Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells.

Abstract Acquired resistance towards apoptosis is a hallmark of cancer. Elimination of cells bearing activated oncogenes or stimulation of tumor suppressor mediators may provide a selection pressure to overcome resistance.…

Continue ReadingSelective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells.
Read more about the article Pester power and its consequences: do European children’s food purchasing requests relate to diet and weight outcomes?
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Pester power and its consequences: do European children’s food purchasing requests relate to diet and weight outcomes?

Abstract Children may influence household spending through 'pester power'. The present study examined pestering through parent-child food shopping behaviours in relation to children's diet and weight status. Cross-sectional and prospective…

Continue ReadingPester power and its consequences: do European children’s food purchasing requests relate to diet and weight outcomes?
Read more about the article Efficacy of neck circumference to identify metabolic syndrome in 3-10 year-old European children: Results from IDEFICS study.
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Efficacy of neck circumference to identify metabolic syndrome in 3-10 year-old European children: Results from IDEFICS study.

Abstract Several studies demonstrated that larger neck circumference (NC) in children and adolescents may help to identify obesity and cardio-metabolic abnormalities. We aimed to evaluate the correlation between NC and…

Continue ReadingEfficacy of neck circumference to identify metabolic syndrome in 3-10 year-old European children: Results from IDEFICS study.
Read more about the article The association between IgG and IgM antibodies against cardiolipin, β2-glycoprotein I and Domain I of β2-glycoprotein I with disease profile in patients with multiple sclerosis.
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The association between IgG and IgM antibodies against cardiolipin, β2-glycoprotein I and Domain I of β2-glycoprotein I with disease profile in patients with multiple sclerosis.

Abstract Antiphospholipid antibodies (aPL) occur in patients with multiple sclerosis (MS) with a number of studies reporting elevated levels; their exact prevalence and pathogenic role remain unclear. Epidemiological studies associate…

Continue ReadingThe association between IgG and IgM antibodies against cardiolipin, β2-glycoprotein I and Domain I of β2-glycoprotein I with disease profile in patients with multiple sclerosis.
Read more about the article HLA-G 14-bp polymorphism affects the age of onset in Type I Diabetes Mellitus.
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HLA-G 14-bp polymorphism affects the age of onset in Type I Diabetes Mellitus.

Abstract Type I diabetes mellitus (T1DM) is an organ-specific autoimmune disorder affecting the insulin-producing pancreatic cells. T1DM genetic association studies have so far revealed the involvement of more than 40…

Continue ReadingHLA-G 14-bp polymorphism affects the age of onset in Type I Diabetes Mellitus.
Read more about the article Human Mesenchymal Stem Cells in Cancer Therapy.
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Human Mesenchymal Stem Cells in Cancer Therapy.

Abstract Human mesenchymal stem cells (hMSCs) have the ability to differentiate into several tissue types. Their use in cancer therapeutics or as therapeutic delivery vehicles has significant potential, particularly in…

Continue ReadingHuman Mesenchymal Stem Cells in Cancer Therapy.
Read more about the article The Importance of Mutational Drivers in GBM.
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The Importance of Mutational Drivers in GBM.

Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor, providing few effective therapeutic options, given the tumor heterogeneity and the accumulation of different genetic abnormalities that cause treatment failure.…

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Frequency of the CCR5-delta32 allele in Brazilian populations: A systematic literature review and meta-analysis.

Abstract The CCR5 is a chemokine receptor widely expressed by several immune cells that are engaged in inflammatory responses. Some populations have individuals exhibiting a 32bp deletion in the CCR5…

Continue ReadingFrequency of the CCR5-delta32 allele in Brazilian populations: A systematic literature review and meta-analysis.
Read more about the article The molecular spectrum and distribution of haemoglobinopathies in Cyprus: a 20-year retrospective study.
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The molecular spectrum and distribution of haemoglobinopathies in Cyprus: a 20-year retrospective study.

Abstract Haemoglobinopathies are the most common monogenic diseases, posing a major public health challenge worldwide. Cyprus has one the highest prevalences of thalassaemia in the world and has been the…

Continue ReadingThe molecular spectrum and distribution of haemoglobinopathies in Cyprus: a 20-year retrospective study.
Read more about the article Advances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome.
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Advances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome.

Abstract Alport syndrome (AS) is a genetic disease characterized by haematuric glomerulopathy variably associated with hearing loss and anterior lenticonus. It is caused by mutations in the COL4A3, COL4A4 or…

Continue ReadingAdvances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome.