Read more about the article Differential expression of parental alleles of BRCA1 in human preimplantation embryos.
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Differential expression of parental alleles of BRCA1 in human preimplantation embryos.

Abstract Gene expression from both parental genomes is required for completion of embryogenesis. Differential methylation of each parental genome has been observed in mouse and human preimplantation embryos. It is…

Continue ReadingDifferential expression of parental alleles of BRCA1 in human preimplantation embryos.
Read more about the article KRAS and the Reality of Personalized Medicine in Non-small Cell Lung Cancer.
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KRAS and the Reality of Personalized Medicine in Non-small Cell Lung Cancer.

Abstract Lung cancer is the leading cause of mortality among all cancer types, worldwide. Latest available global statistics of World Health Organization report 1.59 million casualities in 2012 alone. Worldwide,…

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Read more about the article Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd.
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Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd.

Abstract Gene expression data are accumulating exponentially in public repositories. Reanalysis and integration of themed collections from these studies may provide new insights, but requires further human curation. Here we…

Continue ReadingExtraction and analysis of signatures from the Gene Expression Omnibus by the crowd.
Read more about the article Associations between social vulnerabilities and dietary patterns in European children: the Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS (IDEFICS) study.
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Associations between social vulnerabilities and dietary patterns in European children: the Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS (IDEFICS) study.

Abstract Socio-economic inequalities in childhood can determine dietary patterns, and therefore future health. This study aimed to explore associations between social vulnerabilities and dietary patterns assessed at two time points,…

Continue ReadingAssociations between social vulnerabilities and dietary patterns in European children: the Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS (IDEFICS) study.
Read more about the article Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
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Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.

Abstract Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from…

Continue ReadingEvidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
Read more about the article A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics.
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A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics.

Abstract Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism…

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Read more about the article Clinical radiological correlation in E200K familial Creutzfeldt-Jakob disease.
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Clinical radiological correlation in E200K familial Creutzfeldt-Jakob disease.

Abstract The use of diffusion MRI improved the accuracy of diagnosis in Creutzfeldt-Jakob disease (CJD) and expanded our knowledge of the changes occurring in the brain during the disease. The…

Continue ReadingClinical radiological correlation in E200K familial Creutzfeldt-Jakob disease.
Read more about the article Detection of a Yersinia pestis gene homologue in rodent samples.
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Detection of a Yersinia pestis gene homologue in rodent samples.

Abstract A homologue to a widely used genetic marker, pla, for Yersinia pestis has been identified in tissue samples of two species of rat (Rattus rattus and Rattus norvegicus) and…

Continue ReadingDetection of a Yersinia pestis gene homologue in rodent samples.
Read more about the article Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).
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Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).

Abstract Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high…

Continue ReadingFine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).
Read more about the article Longitudinal associations of lifestyle factors and weight status with insulin resistance (HOMA-IR) in preadolescent children: the large prospective cohort study IDEFICS.
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Longitudinal associations of lifestyle factors and weight status with insulin resistance (HOMA-IR) in preadolescent children: the large prospective cohort study IDEFICS.

Abstract This study investigates prospective associations of anthropometrical and lifestyle indices with insulin resistance (IR) in European children from the IDEFICS cohort. Insulin resistance (IR) is a growing concern in…

Continue ReadingLongitudinal associations of lifestyle factors and weight status with insulin resistance (HOMA-IR) in preadolescent children: the large prospective cohort study IDEFICS.