Read more about the article iLIR database: A web resource for LIR motif-containing proteins in eukaryotes.
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iLIR database: A web resource for LIR motif-containing proteins in eukaryotes.

Abstract Atg8-family proteins are the best-studied proteins of the core autophagic machinery. They are essential for the elongation and closure of the phagophore into a proper autophagosome. Moreover, Atg8-family proteins…

Continue ReadingiLIR database: A web resource for LIR motif-containing proteins in eukaryotes.
Read more about the article The Impacts of miRNAs in Glioblastoma Progression.
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The Impacts of miRNAs in Glioblastoma Progression.

Abstract miRNAs are short noncoding RNA sequences that cause translational repression or mRNA degradation. A growing number of studies have sought new biomarkers in GBM that will be important in…

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Read more about the article Ethical Dilemmas for Oocyte Donations: Slippery Slope for Conflicts of Interest.
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Ethical Dilemmas for Oocyte Donations: Slippery Slope for Conflicts of Interest.

Abstract Oocyte donations have increased with improvements in oocyte cryopreservation procedures in recent years. Women with medical conditions that require chemotherapy or radiotherapy have begun to opt for oocyte cryo¬preservation…

Continue ReadingEthical Dilemmas for Oocyte Donations: Slippery Slope for Conflicts of Interest.
Read more about the article Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes.
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Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes.

Abstract The insufficient ability of specialized cells such as neurons, cardiac myocytes, and epidermal cells to regenerate after tissue damage poses a great challenge to treat devastating injuries and ailments.…

Continue ReadingDirect conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes.
Read more about the article KRAS and the Reality of Personalized Medicine in Non-small Cell Lung Cancer.
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KRAS and the Reality of Personalized Medicine in Non-small Cell Lung Cancer.

Abstract Lung cancer is the leading cause of mortality among all cancer types, worldwide. Latest available global statistics of World Health Organization report 1.59 million casualities in 2012 alone. Worldwide,…

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Read more about the article Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity.
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Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity.

Abstract Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary…

Continue ReadingLoss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity.
Read more about the article On the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis.
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On the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis.

Abstract Neuroimaging studies have reported structural and physiological differences that could help understand the causes and development of Autism Spectrum Disorder (ASD). Many of them rely on multisite designs, with…

Continue ReadingOn the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis.
Read more about the article Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
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Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.

Abstract There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-acting variants represent an important source of phenotypic variation. Consequently, cis-regulatory SNPs associated…

Continue ReadingAssociation of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
Read more about the article DNA sequencing confirms PCR-RFLP identification of wild caught Larroussius sand flies from Crete and Cyprus.
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DNA sequencing confirms PCR-RFLP identification of wild caught Larroussius sand flies from Crete and Cyprus.

Abstract Many Phlebotomine sand fly species (Diptera, Psychodidae) are vectors of the protozoan parasite Leishmania causing a group of diseases called the leishmaniases. The subgenus Larroussius includes sand fly vectors…

Continue ReadingDNA sequencing confirms PCR-RFLP identification of wild caught Larroussius sand flies from Crete and Cyprus.
Read more about the article Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms.
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Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms.

Abstract A recent analysis using family history weighting and co-observation classification modeling indicated that BRCA1 c.594-2A > C (IVS9-2A > C), previously described to cause exon 10 skipping (a truncating…

Continue ReadingCombined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms.