Read more about the article Monitoring opioid and benzodiazepine use and abuse: Is oral fluid or urine the preferred specimen type?
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Monitoring opioid and benzodiazepine use and abuse: Is oral fluid or urine the preferred specimen type?

Abstract Oral fluid (OF) has become an increasingly popular matrix to assess compliance in pain management and addiction settings as it reduces the likelihood of adulteration. However, drug concentrations and…

Continue ReadingMonitoring opioid and benzodiazepine use and abuse: Is oral fluid or urine the preferred specimen type?
Read more about the article Combined effect of glutamine at position 70 of HLA-DRB1 and alanine at position 57 of HLA-DQB1 in type 1 diabetes: An epitope analysis.
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Combined effect of glutamine at position 70 of HLA-DRB1 and alanine at position 57 of HLA-DQB1 in type 1 diabetes: An epitope analysis.

Abstract The contribution of specific HLA Class II alleles in type 1 diabetes is determined by polymorphic amino acid epitopes that direct antigen binding therefore, along with conventional allele frequency…

Continue ReadingCombined effect of glutamine at position 70 of HLA-DRB1 and alanine at position 57 of HLA-DQB1 in type 1 diabetes: An epitope analysis.
Read more about the article Transforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion.
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Transforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion.

Abstract Tumor microenvironment consists of the extracellular matrix (ECM), stromal cells, such as fibroblasts (FBs) and cancer associated fibroblasts (CAFs), and a myriad of soluble factors. In many tumor types,…

Continue ReadingTransforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion.
Read more about the article Intrathecal gene therapy in mouse models expressing CMT1X mutations.
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Intrathecal gene therapy in mouse models expressing CMT1X mutations.

Abstract Gap junction beta-1 (GJB1) gene mutations affecting the gap junction protein connexin32 (Cx32) cause the X-linked Charcot-Marie-Tooth disease (CMT1X), a common inherited neuropathy. Targeted expression of virally delivered Cx32…

Continue ReadingIntrathecal gene therapy in mouse models expressing CMT1X mutations.
Read more about the article Meta-Analysis of Common and Rare Variants.
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Meta-Analysis of Common and Rare Variants.

Abstract Meta-analysis is a statistical technique that is widely used for improving the power to detect associations, by synthesizing data from independent studies, and is extensively used in the genomic…

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Read more about the article Rothmund-Thomson Syndrome: Insights from New Patients on the Genetic Variability Underpinning Clinical Presentation and Cancer Outcome.
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Rothmund-Thomson Syndrome: Insights from New Patients on the Genetic Variability Underpinning Clinical Presentation and Cancer Outcome.

Abstract Biallelic mutations in gene, a caretaker of the genome, cause Rothmund-Thomson type-II syndrome (RTS-II) and confer increased cancer risk if they damage the helicase domain. We describe five families…

Continue ReadingRothmund-Thomson Syndrome: Insights from New Patients on the Genetic Variability Underpinning Clinical Presentation and Cancer Outcome.
Read more about the article Current Status and Future Prospects of Small-molecule Protein-protein Interaction (PPI) Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).
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Current Status and Future Prospects of Small-molecule Protein-protein Interaction (PPI) Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).

Abstract The overexpression of Tumor Necrosis Factor (TNF) is directly related to the development of several autoimmune diseases, such as rheumatoid and psoriatic arthritis, inflammatory bowel disease, Crohn's disease, refractory…

Continue ReadingCurrent Status and Future Prospects of Small-molecule Protein-protein Interaction (PPI) Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).
Read more about the article Constructing the genetic population demography of the invasive lionfish Pterois miles in the Levant Basin, Eastern Mediterranean.
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Constructing the genetic population demography of the invasive lionfish Pterois miles in the Levant Basin, Eastern Mediterranean.

Abstract The recent invasion of the lionfish Pterois miles to the Mediterranean draws major concerns to the fate of the indigenous ecosystem, based on previous knowledge of the species' detrimental…

Continue ReadingConstructing the genetic population demography of the invasive lionfish Pterois miles in the Levant Basin, Eastern Mediterranean.
Read more about the article Sequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain.
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Sequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain.

Abstract Studies proposed a model for embryonic neurogenesis where the expression levels of the SOXB2 and SOXB1 factors regulate the differentiation status of the neural stem cells. However, the precise…

Continue ReadingSequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain.
Read more about the article Omega-3 Fatty Acids Supplementation: Therapeutic Potential in a Mouse Model of Stargardt Disease.
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Omega-3 Fatty Acids Supplementation: Therapeutic Potential in a Mouse Model of Stargardt Disease.

Abstract To evaluate the therapeutic effects of omega-3 (ω3) fatty acids on retinal degeneration in the ABCA4-/- model of Stargardt disease when the blood level of arachidonic acid (AA)/eicosapentaenoic acid…

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